Best Instagram Influencers with American Background (2025)

Published: March 21, 2025

Curated selection of Instagram influencers with American backgrounds, featuring diverse niches from lifestyle to science. Notable figures include MrBeast and Gary Vaynerchuk. Explore influencers with unique content and significant followings. To explore more influencers, visit our platform.

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Micro(10K-100K)

Shares relatable parenting and lifestyle content with a focus on family and product reviews.
1
Profile avatar of "ally ✿ iowa content creator" on "instagram"

@werethewolffs

ally ✿ iowa content creator

Content Focus

parenting | lifestyle | product reviews

your relatable mom friend🤘🏻 dental assistant • raising boys • hockey wife inquiries: werethewolffs@gmail.com

49.7K
followers
859
posts

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Macro(100K-1M)

Miami-based creator sharing beauty, lifestyle, and faith content with a vibrant community.
1
Profile avatar of "Jess ✨ | Miami Creator | Lifestyle & Beauty" on "instagram"

@onlyonejess_

Jess ✨ | Miami Creator | Lifestyle & Beauty

Content Focus

lifestyle | beauty | faith

🧑‍🧑‍🧒Jess, Jonathan & Jacquez 🐱 ▪️Believer ✝️ |📍MIA ▪️beauty | lifestyle | faith ▪️💌| OnlyOneJessXO@gmail.com ▪️570k subscribers | 60 million Views

154.1K
followers
1.0K
posts
Shares style and lifestyle insights with a focus on home and personal experiences.
2
Profile avatar of "payton sartain" on "instagram"

@paytonsartain

payton sartain

Content Focus

style | home | lifestyle

style, home, baseball, 2025 bride texas girl on the east coast @ntsbyps @rsvpdinnerparty

150.4K
followers
3.1K
posts
Offers relatable lifestyle and travel content with engaging personal vlogs.
3
Profile avatar of "Rachel Kwon" on "instagram"

@rachelheheh

Rachel Kwon

Content Focus

Lifestyle | Travel | Personal Vlogs

📍🇰🇷🇺🇸 YouTube: Rachel Kwon 💌rachel@teamwildent.com

504.7K
followers
317
posts
Shares dynamic tennis and pickleball content with sports enthusiasts.
4
Profile avatar of "Rachel Stuhlmann" on "instagram"

@rstuhlmann

Rachel Stuhlmann

Content Focus

Tennis | Pickleball | Sports Consulting

Tennis & Pickleball Content Creator, Correspondent & Consultant🎾 📍Miami Open Mar 19-25 Business inquiries - rachel@outshinetalent.com

304.8K
followers
274
posts

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Mega(1M+)

Engages with social commentary and LGBTQ+ advocacy through vibrant, inclusive content.
1
Profile avatar of "matt bernstein" on "instagram"

@mattxiv

matt bernstein

Content Focus

social commentary | LGBTQ+ advocacy | podcasting

friendly queer jew with very long nails host of @abitfruitypod

1.8M
followers
945
posts
Dynamic gaming and streaming influencer with a strong media presence and community engagement.
2
Profile avatar of "rae" on "instagram"

@valkyrae

rae

Content Focus

video games | streaming | podcasting

hihi:) I stream video games my media company @hihistudios podcast @pressescpod co-owner @100thieves valkyrae@rangemp.com

3.4M
followers
888
posts
Blends comedy and journalism, offering unique Midwest humor and insightful commentary.
3
Profile avatar of "Charlie Berens" on "instagram"

@charlieberens

Charlie Berens

Content Focus

Comedy | Standup | Journalism

Standup Comedian | Emmy-Winning Journalist | NYT Best Selling Author Creator of @manitowocminute and @cripescast Good Old Fashioned Tour Dates 👇

1.2M
followers
2.2K
posts
Promotes gym positivity and personal development with motivational fitness content.
4
Profile avatar of "Joey Swoll" on "instagram"

@joeyswoll

Joey Swoll

Content Focus

Fitness | Gym Motivation | Personal Development

CEO of GYM POSITIVITY Owner: @taste_flavorco COACHING: 📧 joey@joeyswoll.com

5.0M
followers
2.3K
posts
Creates viral entertainment and philanthropy content, captivating a massive global audience.
5
Profile avatar of "MrBeast" on "instagram"

@mrbeast

MrBeast

Content Focus

Entertainment | Challenges | Philanthropy

My New Show Beast Games is out now on Prime Video!

66.7M
followers
370
posts
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Advocates for STEM education and space exploration with engaging science content.
6
Profile avatar of "Emily Calandrelli" on "instagram"

@thespacegal

Emily Calandrelli

Content Focus

Aerospace | Science Education | STEM Advocacy

MIT Aerospace engineer + Emmy-nominated TV host ✍🏻#1 NYTimes Best Selling Author ▶️ Emily's Science Lab on YouTube 🧑🏼‍🚀100th Woman in Space

1.1M
followers
2.7K
posts
Blends corporate humor with entrepreneurship insights, engaging over a million followers.
7
Profile avatar of "Corporate Natalie" on "instagram"

@corporatenatalie

Corporate Natalie

Content Focus

comedy | entrepreneurship | corporate culture

CEO of Work-From-Home Jokes | 🎙️Co-host @demotedpodcast | Co-founder @expand.va | @forbesunder30

1.2M
followers
1.4K
posts
Empowers followers with financial literacy and wealth-building strategies.
8
Profile avatar of "Vivian Tu | Your Rich BFF" on "instagram"

@your.richbff

Vivian Tu | Your Rich BFF

Content Focus

Personal finance | Wealth building | Financial education

💵 Wall Street Girly & NYT Bestseller helping YOU get RICH 💻Email: business@yourRichBFF.com 🎤DM “PODCAST” to listen to @networthandchillpod!

3.4M
followers
1.6K
posts
Delivers engaging medical education and wellness tips to millions.
9
Profile avatar of "𝐃𝐫. 𝐌𝐢𝐤𝐞 𝐕𝐚𝐫𝐬𝐡𝐚𝐯𝐬𝐤𝐢" on "instagram"

@doctor.mike

𝐃𝐫. 𝐌𝐢𝐤𝐞 𝐕𝐚𝐫𝐬𝐡𝐚𝐯𝐬𝐤𝐢

Content Focus

Health | Medical Education | Wellness

Be Aware Of Fake Accounts! @thecheckuppodcast <—New Podcast 🎙️YouTube (13 Million)

4.5M
followers
988
posts
Inspires with motivational entrepreneurship and social media strategies.
10
Profile avatar of "Gary Vay-Ner-Chuk" on "instagram"

@garyvee

Gary Vay-Ner-Chuk

Content Focus

Entrepreneurship | Motivation | Social Media

✈️CEO/Chairman @vaynermedia 🐈‍⬛Creator @veefriends / Founder @vcrgroup 🔮Investor FB,Venmo,Twitter,Liquid Death ✍️I do not have a Telegram account❌ ⬇️

10.5M
followers
10.0K
posts

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